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Although the reign of Alexander the Great was relatively short, his conquests and the power structure that followed him were sufficient to ensure the emergence of an whole new cultural paradigm in the Eastern Mediterranean sea and the Middle East, all the way towards the shores of the Indus.
Thus the Empire of Alexander the Great is but the short stepping stone for the empires/kingdoms of his successors, the Diadochi:
Antipater
Cassander
Craterus
Lysimachus
Ptolemy
Perdiccas
Seleucus
The Empires Project 